TOWARDS ONLINE TRIGGERING FOR THE RADIO DETECTION OF AIR SHOWERS USING DEEP NEURAL NETWORKS


pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model.

Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing.Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the first-line chemotherapeutic drug in the clinic for PDAC treatment.The therapeutic limitations of GEM are primaril

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Zika virus: mapping and reprogramming the entry

Abstract Background The flaviviridae family comprises single-stranded RNA viruses that enter cells via clathrin-mediated pH-dependent endocytosis.Although the initial events of the virus entry have been already identified, data regarding intracellular virus trafficking and delivery to the replication site are limited.The purpose of this study was t

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Using the behavior change wheel to identify barriers to and potential solutions for primary care clinical guideline use in four provinces in South Africa

Abstract Background Clinical practice guidelines risk having yale law school colors little impact on healthcare if not effectively implemented.Theory informed, targeted implementation may maximise their impact.Our study explored barriers to and facilitators of guideline implementation and use by South African primary care nurses and allied healthca

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